Inhibition of Rac 1 Protect Against Platelet Induced Liver and Kidney ‎Injury in Diabetes Mellitus

Diabetes mellitus both (Type 1 and Type 2) are one of the common causes for activation platelet. Inflammation-induced abnormal platelet function contributes to chronic complications, which leading death morbidity among diabetics. Rac1 has been shown regulate a variety functions; predicted Rac1could release CXCL4, leads kidney injury in Mellitus. mellitus' effect on activation, 21kD G-protein implicated was investigated induced inflammation injury. Swiss albino male mice were pretreated with 5 mg/kg specific inhibitor NSC23766 injected (45 body wt.) streptozotocin, twice five days. Moreover, concentration serum chemokines CXCL4 assayed using ELISA histology score examined. Our results showed that by streptozotocin. In addition, (CXCL4) markedly higher diabetic when compared sham (control) group. pretreatment decreased liver assessed score, P-value <0.05. study reveals critical role secretion due diabetes-induced kidneys, targeting could be target innovative treatment control individual. Targeting platelets involved inflammatory pathways part strategy order manage diabetes its consequences.